# C37C3.8 has a conserved non-canonical initiation codon (probably!)

**URL:** <https://community.alliancegenome.org/t/c37c3-8-has-a-conserved-non-canonical-initiation-codon-probably/5496>\
**Category:** WormBase\
**Created:** [February 17, 2017, 5:19pm UTC](https://community.alliancegenome.org/t/c37c3-8-has-a-conserved-non-canonical-initiation-codon-probably/5496 "2017-02-17T17:19:56Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![gw3](https://community.alliancegenome.org/letter_avatar_proxy/v4/letter/g/b4bc9f/32.png) [@gw3](https://community.alliancegenome.org/u/gw3)\
**Post date:** [February 17, 2017, 5:19pm UTC](https://community.alliancegenome.org/t/c37c3-8-has-a-conserved-non-canonical-initiation-codon-probably/5496/1 "2017-02-17T17:19:56Z")

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C37C3.8 probably has a conserved non-canonical initiation codon.

The first exon of orthologs of the CDS C37C3.8c has an ORF with a conserved a coding sequence.  
It is highly likely that the initiation starts with the first Isoleucine residue.

`brenneri\_CBN00990 VIGGLKTTRGGPK-RRRRPAQDQRGP–LQYHP-RRDDTSEAIQSNCVLPLPPSFSHTLH  
elegans\_C37C3.8 VIGRLKTTRGGPT-RRRRPAQDQRGP–LQYHP-RRD-TSNAKQSNCLT–EPS-NHSLH  
remanei\_CRE18617 VIGGSKTTRGGPT-RRRRPAQDQRGPPLQQHHPPRRD-TSEANKSTCVT------VFSFQ  
briggsae\_CBG20564 VIGGLKSSRGCPTTRRRRPAQDQRGPHPLKYHPYRRD-TSAEA-SNCVT-----QQPTSS  
\*\*\* _::_\* _. \*\*\*\*\*\*\*\*\*\*\*\* ::_\* \*\*\* \*_.__._:: :

brenneri\_CBN00990 AFFIR  
elegans\_C37C3.8 TFFLR  
remanei\_CRE18617 AFILR  
briggsae\_CBG20564 NFIQR  
\*: \*`

This gene has now been curated so that there is an isoform which uses this region as the first exon and starts with the Isoleucine.

Would anyone like to do some work to confirm this assumption?