# F26D11.1 has an unusual 5' end

**URL:** <https://community.alliancegenome.org/t/f26d11-1-has-an-unusual-5-end/5434>\
**Category:** WormBase\
**Created:** [September 9, 2016, 2:47pm UTC](https://community.alliancegenome.org/t/f26d11-1-has-an-unusual-5-end/5434 "2016-09-09T14:47:14Z")\
**Posts on this page:** 1\
**Page:** 1

<div class="post-metadata">

**Author:** ![gw3](https://community.alliancegenome.org/letter_avatar_proxy/v4/letter/g/b4bc9f/32.png) [@gw3](https://community.alliancegenome.org/u/gw3)\
**Post date:** [September 9, 2016, 2:47pm UTC](https://community.alliancegenome.org/t/f26d11-1-has-an-unusual-5-end/5434/1 "2016-09-09T14:47:14Z")

</div>

F26D11.1 is a conserved locus c.f. C. briggsae CBG08614,  
remanei CRE27490, japonica CJA12219.

It has a very high level of expression in the first three exons and  
expression decreases to moderately high in the last two exons.

These last two 3’ exons are clearly a CDS.

However, the 5’ three exons can not be made into a CDS in any of the orthologs.

In elegans the 5’ three exons does not have mass-spec evidence, so it is  
unlikely to have a non-canonical initiation site. In elegans the 5’  
region has a polyA site with a lot of supporting evidence.

What is this highly expressed 5’ region?