I was just trawling through the news and found an article about a paper published in Cell describing FOXL2 / SOX9 used to transform between male/female (don’t have access to Cell atm, for the in depth details).
A quick look through WormBase came up with fkh-6 as a potential ortholog of FOXL2 and sox-4 for SOX9, but looking in SPELL for the expression profiles, they don’t seem to be antagonists. Now of course there have been some gene family expansions between C.elegans and the great apes, so the orthology is probably not too clear cut.
I also saw that fkh-6 is named in WormBook as a potential transcription factor involved in male development.
So I was wondering if there is some more information especially about sox-4 and sexual development somewhere hidden, where I can’t find it?
thanks,
Michael