# GO Enrichment Analysis: Putting the Easy in GSEA(y)

**URL:** <https://community.alliancegenome.org/t/go-enrichment-analysis-putting-the-easy-in-gsea-y/7610>\
**Category:** GO\
**Created:** [April 4, 2024, 12:07am UTC](https://community.alliancegenome.org/t/go-enrichment-analysis-putting-the-easy-in-gsea-y/7610 "2024-04-04T00:07:26Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![suzi](https://community.alliancegenome.org/user_avatar/community.alliancegenome.org/suzi/32/606_2.png) [@suzi](https://community.alliancegenome.org/u/suzi)\
**Post date:** [April 4, 2024, 12:07am UTC](https://community.alliancegenome.org/t/go-enrichment-analysis-putting-the-easy-in-gsea-y/7610/1 "2024-04-04T00:07:26Z")

</div>

One of the main uses of the GO is to perform enrichment analysis on gene sets. For example, given a set of genes that are up-regulated under certain conditions, an enrichment analysis will find which GO terms are over-represented (or under-represented) using annotations for that gene set.

Did you know you can do GSEA with just one click? The [home page widget in the GOC website](http://geneontology.org/) connects to the analysis tool from the [PANTHER Classification System](https://pantherdb.org/), which is maintained up to date with GO annotations. In addition to [the 130+ genomes in the widget](https://www.pantherdb.org/panther/summaryStats.jsp), PANTHER supports [another 1100+ genomes](http://data.pantherdb.org/ftp/generic_mapping/stats) from the Reference Proteome project for users to generate GO annotations.

 ![Screenshot 2024-04-03 at 17.55.36](https://community.alliancegenome.org/uploads/default/original/1X/af53d926d2e24eb2001471ccc1e86123fafc018b.png)

➡ [See our quick-help page](https://geneontology.org/docs/go-enrichment-analysis/) for an overview of how to interpret results, including info on background frequency, sample frequency, and p-values.  
➡ Detailed info is available [on the PANTHER site](https://www.pantherdb.org/tips/tips_geneListAnalysis.jsp).  
➡The PANTHER classification system is explained in great detail in [Mi H et al, PMID: 23868073](https://www.ncbi.nlm.nih.gov/pubmed/23868073).  
➡The [list of supported gene IDs](https://www.pantherdb.org/tips/tips_batchIdSearch_supportedId.jsp) is available from the PANTHER website. If your organism is not supported, see our [FAQs](https://geneontology.org/docs/faq/#how-can-i-do-term-enrichment-analysis-for-a-species-that-is-not-present-in-the-list-from-amigo).