Genetic Analysis of Metal-responsive Gene Expression
A postdoctoral research position is available in the Comparative Genomics group in the Laboratory of Toxicology and Pharmacology of the National Institute of Environmental Health Science, NIH in Research Triangle Park, NC (http://www.niehs.nih.gov/research/atniehs/labs/ltp/cg/index.cfm). The Comparative Genomics group is interested in understanding how transition metals contribute to the etiology of human diseases including cancer and developmental abnormalities. Specifically, how metals affect and disrupt intracellular signal cascades and transcription to produce pathological phenotypes. To investigate these phenomena, the group examines the molecular responses associated with transition metal exposure using the nematode C. elegans and mammalian cell culture. A successful candidate will focus on understanding how specific metal responsive genes are regulated in response to cadmium in C. elegans. Modern genomic and genetic techniques as well as classic genetics will be used to search for transcriptional regulators of metal-responsive transcription in C. elegans and ultimately apply this information to studies in mammalian systems.
Applicants must have a Ph.D., M.D., or equivalent degree and less than three years of postdoctoral experience in genetics, molecular biology or an equivalent subject area. Experience performing genetic studies in model organisms is required and C. elegans experience is preferred. NIEHS offers a great post doctoral experience with both research support and professional development programs. It has been rated one of the top places to go for a post doc. For additional information contact Dr. Jonathan Freedman at freedma1@niehs.nih.gov.
To apply submit a cover letter, curriculum vitae, bibliography, and the names of three references to:
Jonathan Freedman, Ph.D.
Laboratory of Molecular Toxicology, DIR, NIEHS, NIH
P.O. Box 12233, Maildrop E1-05
111 Alexander Drive, Room A140A (For Express Mail)
Research Triangle Park, NC 27709
E-mail: freedma1@niehs.nih.gov
The National Institute of Environmental Health Sciences (NIEHS) is located in Research Triangle Park, North Carolina.
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