We are seeking to recruit a post-doc to work on an MRC-funded project which aims to understand how mutations in conserved neuronal genes cause epilepsy.
This will involve using CRISPR to replace orthologous Caenorhabditis elegans genes with single copies of wild-type and mutant human genes.
These humanised worms will be analysed for alterations in neurotransmission and for genetic suppressor screening.
Biochemical/biophysical properties of the corresponding human recombinant proteins will also be analysed in vitro.
You should have (or be about to obtain) a PhD in a biological or biomedical sciences subject.
Laboratory experience with C. elegans, genome editing, genetics/genomics and recombinant protein techniques would be advantageous.
The post is available for 3 years commencing as soon as possible.
For informal enquiries, contact Professor Alan Morgan on (+44) 151 794 5333, or by email at: amorgan@liverpool.ac.uk.
For full details and to apply online, please visit: https://recruit.liverpool.ac.uk
Job Ref: 005584/JAC. Closing Date: 8 March 2017