Postdoc position available to study protein aggregation and turnover in neurodegeneration
The aim of this project is to discover novel pathways of protein degradation in conformational dementias. The collaborative project will profit from the expertise of the Glatzel lab (pathophysiology of neurodegeneration) and the Hoppe lab (protein degradation using Caenorhabditis elegans as a model organism). The Postdoc will be a part of the newly founded research unit “Neuronal Protein Turnover” at the University Medical Center Hamburg Eppendorf and the Centre for Molecular Neurobiology in Hamburg (www.uke.de/for885). Candidates should have laboratory experience. While previous experience in C. elegans is not necessary, this, or experience with a genetic system would be a plus.
Selected Literature:
Accumulation of mutant neuroserpin precedes development of clinical symptoms in familial encephalopathy with neuroserpin inclusion bodies. Galliciotti G., Glatzel M., Kinter J., Kozlov S.V., Cinelli P., Rülicke T., Sonderegger P. (2007). Accumulation of mutant neuroserpin precedes development of clinical symptoms in familial encephalopathy with neuroserpin inclusion bodies. Am J Pathol. 2007 Apr;170(4): 1305-13.
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy. Janiesch P.C., Kim J., Mouysset J., Barikbin R., Lochmüller H., Cassata G., Krause S., and Hoppe T. (2007). Nat. Cell Biol. Apr;9(4): 379-90.
The UNC-45 Chaperone Mediates Sarcomere Assembly through Myosin Degradation in C. elegans. Landsverk M.L., Hutagalung A.H., Li S., Najafov A., Hoppe T., Barral J.M., and Epstein H.F. (2007). J. Cell Biol. 23;177(2): 205-10.
To apply, please forward curriculum vitae, bibliography, and the names and addresses of referees to:
Prof. Dr. Markus Glatzel (Institute of Neuropathology, University Medical Center Hamburg Eppendorf, Martinistraße 52, 20246 Hamburg Germany, m.glatzel at uke.uni-hamburg.de)
or Dr. Thorsten Hoppe (Centre for Molecular Neurobiology Hamburg (ZMNH), Falkenried 94, 20251 Hamburg, Germany, thorsten.hoppe at zmnh.uni-hamburg.de)