Postdoctoral Position: Signaling Underlying Immunity and Behavior- Rubin Lab

A postdoctoral position is available in Charles Rubin’s lab, in the Department of Molecular Pharmacology at Albert Einstein College of Medicine in New York.

Important environmental stimuli trigger increases in intracellular calcium and diacylglycerol (DAG). Signals carried by these second messengers are received, amplified and coupled to the regulation of innate immunity, sodium-dependent associative learning, chemotaxis and pathogen avoidance behavior via activation of a DAG-stimulated RAS guanine nucleotide exchange factor (RGEF-1b) or a DAG-regulated protein kinase C-protein kinase D cascade (pertinent examples and background are provided in references below). Downstream effectors, mechanisms and pathways that link C. elegans PKDs, neuronal DKF-2B and intestinal DKF-2A, to pathogen resistance and avoidance, and chemotaxis behavior are incompletely understood.Thus, we are currently determining how DKF-2B and DKF-2A harness the TIR-1-PMK-1 (p38 MAP kinase pathway), transcription factors and an epigenetic modifier to an upstream, DAG-regulated signaling network. We wish to recruit a motivated, committed and adventurous postdoctoral researcher to work with us on this project. The studies are performed with an integrated multidisciplinary approach. Classical and molecular genetics are used in combination with biochemistry, cell and molecular biology and imaging. This provides a broad and deep learning/training experience in fundamentally important areas of signal transduction. Applicants should have training and experience in genetics and molecular biology. Interested individuals should send, by e-mail, a CV, brief description of research accomplishments and interests and the names and e-mail addresses of three references to:

Charles Rubin, Ph.D.
Department of Molecular Pharmacology
Albert Einstein College of Medicine
1300 Morris Park Avenue
Bronx, New York 10461,USA
Tel:718-430-2505
e-mail: charles.rubin@einstein.yu.edu

References
Chen, L., Fu, Y., Ren, M., Xiao, B. & Rubin, C. S.(2011) A RasGRP, C. elegans RGEF-1b, Couples External Stimuli to behavior by Activating LET-60 (Ras) in Sensory Neurons, Neuron, 70, 51-65.
Ren, M., Feng, H., Fu, Y., Land, M. & Rubin, C.S. (2009) Protein Kinase D (PKD) Is an Essential Regulator of C.elegans Innate Immunity. Immunity 30, 521-532.
Albert Einstein College of Medicine is situated in a pleasant residential area of the Bronx, one of the five boroughs of New York City, and offers ready access to the cultural and recreational opportunities in Manhattan and the greater New York area.