Want to solve the next challenges in cellular reprogramming?
Start Date: 2019 - early 2020
Lab: Sophie Jarriault - http://igbmc.fr/jarriault
Job Description: We are seeking a highly motivated research fellow (PhD, MD or MD/PhD) with strong interest in cellular identity and plasticity.
We have pioneered the study of natural instances of cellular reprogramming establishing the worm as a unique model (see for ex. Jarriault PNAS 2008;
Richard Dev. 2011; Kagias PNAS 2012; Hadjuskova Genesis 2012; Zuryn Science 2014; Becker 2016). We have found that direct reprogramming of the
Y cell involves a first dedifferentiation step, and genetic screens have unravelled a preliminary Gene Regulatory Network driving this event; on-going single
cell RNA Seq studies will further densify this GRN. The project is centered on the nature of the GRN in a single cell and on how its architecture
impacts on the invariant timing of the reprograming event. It will involve genetic, imaging and molecular biology approaches, as well as high throughput
genomics/bioinformatics approaches and modelling.
Scientific Environnement: Our team, supported by an ERC grant, is part of the Cell and Developmental Department, at the IGBMC
in Strasbourg, France. This Research Institute (http://www.igbmc.fr) provides access to state-of-the-art facilities and a vibrant
international research environment, and offers the candidate a unique opportunity to be exposed to multidisciplinary teams and a rich scientific life
(seminars, international meetings, scientific clubs, retreats, postdocs&students board, etc).
Candidate: The successful candidate should have a PhD (or be in the final stages of completion) and be highly motivated with a strong interest
in Developmental and Stem Cells Biology. The ability to work both independently and as a team member and experience in the use of molecular biology
and genetic techniques are essential. Experience in working with C. elegans is a plus, but is not required. Note that a very good track record and at least
one publication as a first author is required.
Apply: Interested applicants should submit a cover letter with research interests, brief statement on their future goals, description of research
experience, curriculum vitae, the names of three referees willing to provide letters of reference to :
Dr. Sophie Jarriault at: sophie@igbmc.fr