Bit of a rhetorical question this but, considering the relatively low cost of HT sequencing, wouldn’t it be a useful exercise to complete the genomes of the other Caenorhabditis spp? Its really frustrating to pull up a briggsae or remanei contig with loads of NNNNNNs in it! Anyone agree?
currently it seems like sequencing capacities are mostly used for sequencing new species or genotyping strains.
As the costs for improving an existing genome are similar to sequencing a new one, the quality improvement would have to be big enough to justify it.
… and yes, the Ns are annoying.