Genes with updated locus descriptions in the past month

SGD curators add new publications and information to the database on a daily basis. Below is a list of genes with updated locus descriptions in the past month. Is your favorite gene on the list?

Systematic Name Gene Name Description
YGR113W DAM1 Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Duo1p and Pse1p to connect the DASH complex with the microtubules (MT); couples kinetochores to the force produced by MT depolymerization, thereby aiding in chromosome segregation; N-terminal staple region is important for self-assembly of the Dam1 complex higher order ring structure that forms around microtubules; Ipl1p target for regulating kinetochore-MT attachments
YGR175C ERG1 Squalene epoxidase; catalyzes epoxidation of squalene to 2,3-oxidosqualene; plays essential role in ergosterol-biosynthesis pathway and is specific target of antifungal drug terbinafine; directed to ER via guided entry of tail-anchored proteins (GET) pathway; degradation by ERAD triggered by membrane lipid saturation; human SQLE functionally complements the lethality of the erg1 null mutation
YLR449W FPR4 Nuclear peptidyl-prolyl cis-trans isomerase (PPIase); impacts expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; role in rDNA maintenance; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; contains a nucleoplasmin-like fold and can form pentamers
YKR011C FPT1 Chromatin-associated negative regulator of RNA polymerase III assembly; differentially and dynamically occupies RNA polymerase III-transcribed genes; promotes eviction of RNAPIII; occupancy depends on TFIIIB and TFIIIC, not RNAPIII; protein abundance increases in response to DNA replication stress
YOR267C HRK1 Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism and under acetic acid stress; plays a role in ion homeostasis; maintains pH homeostasis and modulates plasma membrane potential under acetic acid stress; protein abundance increases in response to DNA replication stress
YLL026W HSP104 Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate denatured, protein aggregates; responds to stresses (heat, ethanol, and sodium arsenite); required for the protein aggregate solid-to-liquid phase transition and dispersal of liquid condensates; involved in [PSI+] propagation; potentiated variants eliminate TDP-43 cytoplasmic aggregates to reduce proteotoxicity; becomes more abundant and forms cytoplasmic foci during replication stress
YDR062W LCB2 Serine palmitoyltransferase component; responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YNL055C POR1 Mitochondrial porin and phospholipid scramblase; voltage-dependent anion channel in the outer mitochondrial membrane (OMM) required for maintenance of mitochondrial osmotic stability and membrane permeability; scramblase involved in mitochondrial transbilayer translocation of phospholipids; couples glutathione pools of the intermembrane space (IMS) and the cytosol; phosphorylated; protein abundance increases in response to DNA replication stress; orthologous to human VDAC1 and VDAC2
YKR072C SIS2 Negative regulatory subunit of protein phosphatase 1 (Ppz1p); involved in coenzyme A biosynthesis; subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC: Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p); dose-dependent regulator of replicative lifespan; SIS2 has a paralog, VHS3, that arose from the whole genome duplication
YDR275W TLD1 Protein that regulates lipolysis; inhibits oxidative damage induced by amphotericin B; overexpression increases flocculation, biofilm formation, invasive and pseudohyphal growth; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; null mutant displays increased translation rate and increased readthrough of premature stop codons; TLD1 has a paralog, IRC23, that arose from the whole genome duplication
YGR285C ZUO1 Ribosome-associated co-chaperone; zuotin functions in ribosome biogenesis and as a chaperone for nascent polypeptide chains with Ssz1p and Ssb1/2p; subunit of the ribosome-associated complex (RAC) that stimulates Ssb1/2p ATPase activity to facilitate interaction with nascent polypeptide chains emerging from the ribosome exit tunnel; regulates translation upon inhibition of TORC1; contains a DnaJ domain; human gene DNAJC2 partially complements the yeast zuo1 null mutant
YGR054W Eukaryotic initiation factor eIF2A; associates specifically with both 40S subunits and 80S ribosomes, and interacts genetically with both eIF5b and eIF4E; physically interacts with Ssd1p, and associates with mRNAs encoding proteins required for cell wall organization, and some of which require the presence of Ssd1p; translational repressor of cell wall-related proteins; interacts physically and genetically with Xrn1p; homologous to mammalian eIF2A
YKL069W Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; capable of binding and degrading patulin, a polyketide mycotoxin, forming E-ascladiol; relative distribution to the nucleus increases upon DNA replication stress