In the latest iScience issue, Jacobson et al. examine extracellular matrix (ECM) protein dynamics in the mouse embryo. They found distinct differences when compared to other developing organs, and alterations in the disease model for osteogenesis imperfecta murine. This publication shows ECM protein dynamics cannot be predicted by transcriptomics, and will help future investigation of the matrisome during complex tissue development.
Excerpt &Fig 2C from Jacobson et al. (read the open access paper here):
GO analysis of the matrisome components that were significantly more abundant in (Figure 2B), or exclusive to, E12.5 or E14.5 forelimbs generated distinct and shared developmental terms (Figures 2C; Table S2). “Sensory system”, “blood vessel”, and “organ development” were significant at E12.5. The latter two terms were also significant at E14.5, as well as “tendon”, “skeletal system”, and “connective tissue development”.
