Homologs of the Hh signalling network in C. elegans

A few updates to the chapter Homologs of the Hh signalling network in C. elegans

The reference for the paper on wrt-5 is
Hao L, Aspöck G, Bürglin TR: The hedgehog-related gene wrt-5 is essential for hypodermal development in Caenorhabditis elegans. Dev Biol 2006, 290(2):323-336.

The reference for the paper on qua-1 is
Hao L, Mukherjee K, Liegeois S, Baillie D, Labouesse M, Bürglin TR: The hedgehog-related gene qua-1 is required for molting in Caenorhabditis elegans. Dev Dyn 2006, 235(6):1469-1481

qua-1 has also been found in the molting gene screen by Frand et al. (2005): Frand AR, Russel S, Ruvkun G: Functional genomic analysis of C. elegans molting. PLoS Biol 2005, 3(10):e312.

A survey of grd and grl expression patterns can be found in
Hao L, Johnsen R, Lauter G, Baillie D, Bürglin TR: Comprehensive analysis of gene expression patterns of hedgehog-related genes. BMC Genomics 2006, 7:280.

Some of the online supplementary information in Aspöck G, Kagoshima H, Niklaus G, Bürglin TR: Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis. Genome Res 1999, 9(10):909-923. is missing on the Genome Research Web site. It can be found at wartsupinfo.html

Recently, Liégeois et al. (2006) have shown that Hedgehog-related proteins are secreted apically in exosomes mediated by V0-ATPase:
Liégeois S, Benedetto A, Garnier JM, Schwab Y, Labouesse M: The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans. J Cell Biol 2006, 173(6):949-961.