I think that there is an incorrect link between ins-2 and ins-17 in wormbase.
Under ins-17, it lists ins-2 as an alternate name. This is not reciprocated in the ins-2 entry.
The ins-2 entry lists no alleles/strains
The ins-17 entry lists 2 alleles (ok2488 tm790) and no strains.
The ins-3 entry lists 2 alleles (ok2488 tm3608) and 1 strain (RB1915)
The RB1915 strain entry lists the genotype ins-3(ok2488) II.
The allele info for ok2488 lists the corresponding genes ins-3 and ins-17. For other alleles it only lists ins-3’s alternate allele tm3608.
If you run ins-2, ins-3, and ins-17 through Biomart seeking all available strain info, ins-2 and ins-3 come back with zero hits. ins-17 comes back with 2 identical hits, both listed as strain RB1915, however, this time, RB1915’s genotype is listed as ins-2(ok2488) II.
The sequence names for ins-2 and ins-3 are ZK75.2 and ZK75.3 respectively and are very close to each other (chrom II), however ins-17’s sequence name is F56F3.6 and it’s on a different chromosome than ins-2 or ins-3 (chrom III).
It looks like the deletion ok2488 extends over parts of ins-2 and ins-3.
I think that the ins-2, ins-17 link is falsely defined in some aspects of these genes and not others. Under the allele info for ok2488, the corresponding genes should be ins-2, and ins-3. It’s listing ins-3 and ins-17 probably because it thinks ins-17 is ins-2 in this case.
This is probably what’s causing biomart to assign this strain to ins-17 with the genotype listed as an ins-2 allele.
Am I incorrect in the way I am interpreting this information? Or is there some vital piece of info concerning these genes that I am missing that would explain why there’s some interchanging of gene designations? Or is there probably a mislabel somewhere in the dataset?
Thanks for anyone who can provide some insight into this.