The FlyBase Papers with Technical Advances page has been updated with January’s user submissions https://wiki.flybase.org/wiki/FlyBase:Papers_with_technical_advances#Jan_2026. As always, if you’d like your paper reporting a new technique, reagent, or resource featured in a future update, flag it when you Fast Track Your Paper.
Ecofriendly Fabrication and Hierarchical Exploration of Cytocompatible Lignin Nanoparticles for Biomedical Applications. (ACS Appl Bio Mater)
Lignin nanoparticles exposure decreased ROS levels, maintained glutathione content, and showed no change in H2O2 levels, signifying that LNPs are not inducers of oxidative stress. Enhanced catalase activity upon LNP treatment further supported their antioxidant properties.
https://pubmed.ncbi.nlm.nih.gov/41145431
dFlpTag, a RMCE-based tool for simultaneous endogenous protein tagging and cell labeling in Drosophila. (Sci. Rep.)
dFlpTag is a new tool designed to create both constitutive and conditional protein tagging strains from MiMic or CRIMIC insertions. Moreover, dFlpTag enables co-labeling of the source cells of the protein of interest in a cell type-specific or sparse fashion.
https://pubmed.ncbi.nlm.nih.gov/41310158
Shaping of olfactory responses by taste in a new assay for operant learning in Drosophila melanogaster. (J. Exp. Biol.)
New behavior assay to test operant response to taste and smell in Drosophila
https://pubmed.ncbi.nlm.nih.gov/41122082
The adipose tissue has an apical-basal polarity required for Col IV-dependent cell-cell adhesion. (J. Cell Biol.)
Super resolution imaging of Actin using a Nikon AX-R NSPARC microscope
https://pubmed.ncbi.nlm.nih.gov/41493271
CrisprBuildr: an open-source application for CRISPR-mediated genome engineering in Drosophila melanogaster. (G3 (Bethesda))
Bioinformatics tool to facilitate the planning of CRISPR/Cas9 genome engineering experiments
https://pubmed.ncbi.nlm.nih.gov/41121528
Predicting the functional impact of single nucleotide variants in Drosophila melanogaster with FlyCADD. (Genetics)
FlyCADD is a functional impact prediction tool for single nucleotide variants in D. melanogaster. Adapted from CADD, it integrates >650 genomic features for each possible SNP into an impact prediction score genome-wide, aiding variant prioritization based on functional impact.
https://pubmed.ncbi.nlm.nih.gov/41270030
Allograft transplantation for Drosophila tumor metastasis studies. (Dis. Model Mech.)
We establish timeline of tumor progression following allograft transplantation of primary tissue and upon serial transplantation from one host to another. We show serial transplantation as effective technique for generating cancer metastasis amenable to large-scale studies.
https://pubmed.ncbi.nlm.nih.gov/41163533
Development of an eco-friendly RNAi yeast attractive targeted sugar bait that silences the shaker gene in spotted-wing drosophila, Drosophila suzukii. (Pest Manag. Sci.)
Saccharomyces cerevisiae that expresses shRNA targeting the D suzukii Shaker gene.
https://pubmed.ncbi.nlm.nih.gov/40964941
Kuzbanian expression levels dictate Notch signaling outcomes via interplay between cis- and trans-Delta. (Development)
Kuz-3XHA KI stocks
https://pubmed.ncbi.nlm.nih.gov/41556123
A new system for studying neuronal remodeling and its relation to behavior in Drosophila. (Commun. Biol.)
The study presents a new split GAL4 driver line that specifically and persistently labels the MooSEZ neuron.
https://pubmed.ncbi.nlm.nih.gov/41429933
A mitotic bookmark coordinates transcription and replication in Drosophila embryos. (Nucleic Acids Res.)
Endogenously tagged Fs(1)h
https://pubmed.ncbi.nlm.nih.gov/41474265
Pre-Pulse Inhibition of an escape response in adult fruit fly, Drosophila melanogaster. (Transl. Psychiatry)
We have developed a user-friendly, semi-automated, high-throughput-compatible Drosophila light-off jump response Pre-Pulse Inhibition (PPI) paradigm, with which we demonstrate that PPI, with similar parameters measured in mammals, exists in adults of this model organism.
https://pubmed.ncbi.nlm.nih.gov/41507144
Dopamine production in the central nervous system is important for follicle survival and interacts with genetic background and a high sugar diet during Drosophila oogenesis. (Genetics)
Here, we describe how a mutation on the yellow gene interact with diet (e.g. high sugar diet) to decrease oogenesis by increasing death of the oogenesis stages, early germline cyst and vitellogenic follicle.