The Cutter lab at the University of Toronto is seeking a postdoctoral researcher to study the genetic basis of adaptation and reproductive isolation. The Cutter lab uses Caenorhabditis nematodes related to C. elegans as a model system to investigate these problems in evolutionary genetics. In particular, we are trying to understand how evolutionary adaptation to temperature by C. briggsae manifests in terms of sequence changes to its genome, and to understand the evolution of genetic incompatibilities between C. briggsae and a close relative. To do so, we are applying and developing resources for mapping with advanced intercross recombinant inbred line (RIL) and near isogenic introgression line (NIL) strain libraries, coupled with high-throughput next-generation sequence-based genotyping and functional experiments, to determine the identity and function of quantitative trait nucleotides (QTN).
For recent publications motivating these topics, see:
http://dx.doi.org/10.1016/j.tree.2011.11.004
The ideal candidate will have strong interest in genetics, and strong knowledge of and practical experience in quantitative and/or general genetics, molecular biology, statistics and computation, as well as knowledge in evolutionary biology and a track record of writing and publication. It would also be valuable to have experience working with C. elegans and next-generation sequence data. Applicants should send their CV, a 1-2 page statement of research interests and experience, and the names and contact information for 3 individuals who can speak on their behalf to asher.cutter@utoronto.ca via email.
The Cutter lab is based at the University of Toronto in the Department of Ecology & Evolutionary Biology. The University of Toronto is a leading academic institution in Canada, with exceptional depth of research in evolutionary and molecular genetics. Toronto is a vibrant and multicultural city, offering an exceptional quality of life.
For additional information about the Cutter lab and the EEB department, see: