The laboratory is looking for an outstanding scientist to contribute in deciphering the open questions in the field of RNA repeat toxicity associated with degenerative disorders.
The lab’s goal is to dissect the distinct factors and mechanisms that underlie the processes of cellular degeneration caused by RNAs bearing expanded nucleotide repeats. These toxic repeat-bearing RNAs are associated with a wide number of neuromuscular degenerative disorders from amyotrophic lateral sclerosis (ALS) to Myotonic Dystrophies (DMs). We have established C. elegans models of Myotonic Dystrophy, which results from the presence of RNAs with CUG expansions in the 3’UTR and, using genetic approaches, we identified a group of conserved modulators of cellular toxicity.
Our research aims are: 1) Dissect the mechanisms of toxicity modulation for the genes we have identified as mediators of toxicity in Myotonic Dystrophy (published and unpublished), including the nonsense mediated mRNA decay (NMD) pathway; 2) Identify the full complement of cellular components/pathways that combinatorially regulate the processes of RNA toxicity
Requirements and position details:
- Candidates should be highly motivated and dedicated to research with strong interpersonal and verbal communication skills
- Strong background in C. elegans research
- Experience in RNA biology
- Experience in biochemical approaches is preferable but not a limiting factor
- This position is fully funded for 3 years; there is also access to postdoc fellowships for future exploration
The preferred starting date is as soon as possible.
Relevant Bibliography:
Garcia SMDA, et al (2014) Nat Struct Mol Biol.; 21(8 ):712-20.
The Biotechnology Institute is a multidisciplinary institute with a highly international and collaborative social and scientific environment. It’s situated in the Viiki campus, a lovely location 25min from downtown Helsinki.
If you are interested in joining the lab, please send a cover letter with your research accomplishments and interests (which aspects of the research program would you be interested in pursuing), a current CV, and contact information of at least two references to susanamaria.garcia@helsinki.fi