The Calarco lab, which will join the Center for Systems Biology at Harvard in Spring 2011 is currently accepting applications to hire two post-doctoral fellows for a three year term (with the possibility of extending to five years). Senior PhD students interested in starting post-doctoral work in the next six months to one year are encouraged to apply.
Research in the lab will focus on investigating alternative splicing regulatory networks in the developing and mature nervous system using both mammalian systems and C. elegans. We will be pursuing these questions using a combination of biochemical, cell biological, classical and molecular genetic approaches in addition to genome-wide analyses. We also intend on branching out and investigating the role of other modes of co- and post-transcriptional gene regulation in nervous system development and function. For further details on some of the research we are pursuing, potential candidates can take a look at some recent publications stemming from our work:
Calarco, J. A., Superina, S., O’Hanlon, D., Gabut, M., Raj, B., Pan, Q., Skalska, U., Clarke, L., Gelinas, D., van der Kooy, D., et al. (2009). Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein. Cell 138, 898-910.
*Barash, Y., *Calarco, J. A., Pan, Q., Gao, W.,Wang, X., Shai, O., Blencowe, B. J., Frey, B. J. (2010). Deciphering the Splicing Code. Nature 465(7294):53-9.
*Ramani, A.K., *Calarco, J. A., Pan, Q., Mavandadi, S., Wang, Y., Lee, L.J., Nelson, A.C., Blencowe, B. J., Zhen, M. Fraser, A.G. Genome-wide analysis of alternative splicing in C. elegans. Genome Research (in press).
Candidates should have a strong interest in either RNA processing, other aspects of gene regulation, or neurobiology. Experience with either C. elegans or mammalian cell-based approaches is a plus but not required. We are also very interested in working with exceptional computational biologists who wish to gain more experience with wet-lab techniques. Candidates will be immersed in an exceptional and highly collaborative research environment composed of scientists with diverse interests spanning biology, chemistry, physics, mathematics, computer science, and engineering. For more information about the Center please visit the following link:
http://sysbio.harvard.edu/csb/
Applicants should send their CV, a 1-2 page statement of research interests and experience, and the names and contact information of three individuals who can speak on their behalf to john.calarco@utoronto.ca via e-mail.