This is a MRC-funded postdoctoral position: Investigating the response of resident neural progenitor cells after spinal cord injury (SCI) in regenerative and non-regenerative species
Location: Manchester, UK / Montevideo, Uruguay
Closing Date: 1 October 2023
Start date: 1 October 2023
Closing Date: 1 October 2023
Scientific fields: Regeneration, Neural development, Cell fate control and differentiation
Model systems: Mouse, Xenopus
Duration: Fixed term
Background
Mammals in general – and humans in particular – have a very poor ability to regenerate or repair their central nervous system after injury, with devastating consequences for individuals affected by trauma such as SCIs. Recently, we have focussed our efforts to understand the mechanisms underlying the response to injury and neuronal regeneration in Xenopus, a species able to regenerate its spinal cord after injury. We have shown that the timing and rate of neuronal differentiation is necessary for spinal cord regeneration and precisely controlled (Pelzer et al. 2021, PMID 34427977). Our labs are interested in addressing the following fundamental questions:
– How distinct are the transcriptional programmes of developmental and regenerative neurogenesis?
– Can we identify regeneration-specific mechanisms promoting neurogenesis after injury?
– Can we use this knowledge to stimulate neurogenesis after SCI in mammals?
This project is a collaboration between Dr Karel Dorey (University of Manchester, UK) and Dr Raúl E. Russo (IIBCE, Montevideo, Uruguay). The successful candidate will benefit from a vibrant scientific environment both at the University of Manchester (Regeneration, Neurosciences and Developmental Biology) and in the Instituto de Investigaciones Biológicas Clemente Estable (Neurosciences, Spinal cord injury) with access to state-of-the-art core facilities (in particular Genomics, Animal facilities, Histology, Flow Cytometry and Imaging) and different transgenic animal models. This collaborative project will provide a unique opportunity for the PDRA to acquire in vivo skills to study the spinal cord response to injury both in regenerative and non-regenerative species.
The post is funded for 40 months full time. Closing date for application and starting date tbc. We encourage interested candidates to contact us explaining your past and current research experiences, research interests and long-term goals together with a CV.
For more information, contact Karel Dorey (karel.dorey@manchester.ac.uk) or Raul Russo (rrusso@iibce.edu.uy)