The lab of Amy Shaub Maddox aims to define mechanisms of the mesoscale cytoskeletal remodeling that underlies cell shape dynamics in cell division and development. We use the germline, zygote, blastomeres, and epithelial cells of the nematode C. elegans as complementary model cell types. High-resolution light microscopy is used to follow the dynamics of cell shape and of fluorescently-tagged proteins. Computer-aided image and data analysis are used for innovative quantitative assays. Genome editing and RNA-mediated interference are used to tag and deplete proteins of interest. Agent-based modeling is used to simulate cytoskeletal remodeling and to predict key relationships.
We seek a post-doctoral fellow who will carry out original research on the broad topic of cell shape and morphogenesis. They will employ a variety of modern technologies including genome editing, high-resolution light microscopy, and computer-aided image analysis. They will work largely independently, but will communicate closely with the supervising faculty member, and with other members of the lab team. Primary responsibilities include mastering published literature on the project, devising and carrying out experiments, analyzing data, drafting and finalizing manuscripts, and making oral presentations. Additional responsibilities include training other members of the lab, peer review of manuscripts for journals, and community outreach.
Read more about us at asmlab.web.unc.edu