Postdoctoral position- Modeling the influence of advanced glycation end-products in diabetes and neurodegeneration using C. elegans and mice
The focus of the Kapahi Laboratory is to identify and characterize the mechanisms by which nutrients modulate aging and age-related diseases. This is being achieved by using an interdisciplinary approach combining genetic, pharmacological, biochemical and genomic approaches in invertebrate model systems C. elegans, D. melanogaster and mammalian cells. The broader significance of this research is to help uncover the role of nutrition in the etiology of age-related human diseases like diabetes, obesity and neurodegeneration.
The current position involves developing models for diabetic complications and studying the effects of diet on aging and age-related diseases using C. elegans, mice and IPS derived cells. We propose to examine the mechanisms involved in formation and dealing with Advanced Glycation Endproducts (AGEs). Previous background in worm genetics will be an advantage. The candidate will receive training in specific area(s) of research with the aim of progressing towards an independent career. For more questions regarding this position please e mail Pkapahi@buckinstitute.org or visit Kapahi Lab
- Chaudhuri et al. The role of advanced glycation end products in aging and metabolic diseases: bridging association and causality. Cell Metabolism. free download https://authors.elsevier.com/a/1XgIh5WXUlA-D-
- Chaudhuri, J., Bose, N., Gong, J., Hall, D., Rifkind, A., Bhaumik, D., Peiris, T. H., Chamoli, M., Le, C. H., Liu, J., Lithgow, G. J., Ramanathan, A., Xu, X. Z. and Kapahi, P. “A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive alpha-Dicarbonyl Detoxification.” Curr Biol 26, no. 22 (2016): 3014-3025. PMC5135008
- Chen D, Melov S, Kapahi P. Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans. Cell Reports, 2013
- Rogers AN, Chen D, Czerwieniec G, McColl G, Felkey K, Melov S, Gibson B, Hubbard A, Lithgow GJ, Kapahi P. Post-transcriptional remodeling of longevity and stress response gene expression by inhibition of eIF-4G. Cell Metabolism, 2011
The Buck Institute for Age Research is the only independent institute in the U.S. devoted solely to research on aging and age-related diseases. Our mission is to increase the healthspan, the healthy years of life. Awarded a federal grant to establish interdisciplinary research in a new field called Geroscience, Buck scientists work in a unique, collaborative environment that allows scientists to initiate studies quickly and respond to new opportunities. The Buck Institute has excellent in-house proteomic, genomic and microscopy facilities. Our scientists represent a variety of complementary fields, including genetics, epigenetics, biochemistry, molecular biology, bioenergetics, age-associated disease; and technological disciplines such as genomics, proteomics, protein interaction networks and bio-informatics. The Buck Institute has an excellent postdoctoral research program. There are currently 200 employees, and plans to grow to 550 over the next decade. We offer competitive salaries, excellent benefits, dynamic work environment, and new state-of-the-art facilities. For more information www.buckinstitute.org