POSTDOC POSITIONS AVAILABLE
Schumacher Laboratory
DNA damage and aging
CECAD-Cluster of Excellence in Aging Research, University of Cologne
Institution information: CECAD Cologne Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Zülpicher Str. 47a, 50674 Cologne, Germany
Location: Cologne is a vibrant city with a highly international academic research environment. CECAD forms a focal point of aging research in Europe.
Website: www.uni-koeln.de/inter-fak/cecad/schumacher
Summary: Our research aims at understanding how DNA damage accumulation causes aging. Furthering our knowledge of the mechanisms of cellular responses to accumulating DNA damage will give us a better insight into the biology of aging and might lead to the development of therapeutic strategies aimed at prevention of aging-related diseases.
Job description: We are seeking highly motivated Postdoc candidates for our ERC-funded team investigating the fundamental role of DNA damage in aging. We are using both genetic and biochemical approaches primarily in the C. elegans but also in mammalian systems to investigate the molecular basis of aging.
Qualification: Applicants should have a solid background in molecular biology and experience in cell biology, genetics, or biochemistry. Postdoc candidates should have demonstrated outstanding performance by high impact publications.
How to Apply: Please send CV, letter of intent, names and addresses of three references to bjoern.schumacher@uni-koeln.de
Selected Publications:
Schumacher B. Transcription-blocking DNA damage in aging: a mechanism for hormesis. Bioessays. 2009 Dec;31(12):1347-56.
Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LHF, van der Horst GTJ, Brüning JC, Niessen CM, Hoeijmakers JHJ and Schumacher B. Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nature Cell Biol. 2009 May;11(5):604-15.
Schumacher B, van der Pluijm I, Moorhouse MJ, Rasile Robinson A, Suh Y, Breit TM, van Steeg H, Niedernhofer LJ, van Ijcken W, Bartke A, Spindler SR, Hoeijmakers JHJ, van der Horst GTJ and Garinis GA. Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet. 2008 Aug 15;4(8)e1000161.
Schumacher B, Garinis G, Hoeijmakers J. Age to survive: DNA damage and aging. Trends Genet. 2008 Feb;24(2):77-85.
Schumacher B, Hanazawa M, Lee M, Nayak S, Volkmann K, Hofmann R, Hengartner M, Schedl T, Gartner A. Translational Repression of C. elegans p53 by GLD-1 regulates DNA damage induced apoptosis. Cell, 11 February 2005; 120: 357-368.