The laboratory of Brian Kraemer seeks a motivated individual who works well with others to join a multi-disciplinary collaborative research team focused on the molecular genetics of aging associated neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. We are investigating the molecular mechanisms of aging induced protein aggregation and neurodegeneration using forward genetic approaches. Specifically, we have identified many genetic suppressors of the neurodegenerative phenotype caused by transgenic human tau protein expression in C. elegans neurons. We have identified several intriguing candidate genes ripe for a new postdoctoral researcher to characterize further using behavioral, genetic, and biochemical analyses. By completing these C. elegans studies, we aim to nominate novel therapeutic target genes for translation studies in rodent models of neurodegenerative disease. Dr. Kraemer is faculty at the University of Washington School of Medicine and his laboratory is located on the VA Medical Center Campus in Seattle, Washington. This research project is supported by an NIH funded R01 grant.
Required Qualifications:
• A PhD in a relevant field of the biological sciences.
• Experience designing and executing well controlled experiments.
• Strong writing skills.
• Strong verbal communication skills.
• Ability to work both independently and as a cooperative part of a team.
• Eligibility for work/training in the USA.
Additional desirable experience/knowledge include:
• Experience in genome editing using CRIPSR/Cas9.
• Experience designing, cloning, and generating transgenic C. elegans strains.
• Experience with both forward and reverse genetic analysis methods.
• Experience in assessing protein aggregation.
• Knowledge of RNA binding protein function.
• Knowledge of the pathobiology of neurodegenerative disease
• Knowledge of the biology of aging and disease
Compensation will be consistent with UW postdoctoral pay scale. Please contact Brian Kraemer at kraemerb@uw.edu to express interest in the position.