Objective: employ C. elegans to identify and study the function of genes that cause rare disorders in humans, as a component of the NIH Undiagnosed Disease Network (UDN). As part of a team effort with other researchers and clinicians, candidate disease gene-variants are identified, knocked into the worm ortholog by Cas9/CRISPR and phenotype assessed. The development of a follow-up independent research program from one or more of the cases is possible. The project is performed under the guidance of Tim Schedl & Stephen Pak, co-directors of the Washington University School of Medicine Undiagnosed Disease Network Worm Model Organism Screening Center.
Applicants must have completed PhD, MD or foreign equivalent. Experience in C. elegans, genetics, molecular, cellular, developmental or neuro-biology is advantageous, but not required. The desired candidate is a team player with a strong work ethic. International scientists and US citizens are equally eligible for these fully funded positions.
Washington University is a premier medical research institution, highly collaborative with strengths in model organism basic science and clinical research. St Louis is a diverse multi-cultural environment that is friendly, very affordable and has easy access to numerous indoor and outdoor activities.
For more information or to apply, email Tim Schedl < firstname.lastname@example.org >. To apply, send cover letter, a CV and contacting formation for three letters of reference.