The laboratory of Steven Zuryn (www.zurynlab.com) focuses on fundamental aspects of mitochondrial genomics, such as mosaicism, quality control, and inheritance. We combine genetics, biochemical and genomic approaches to identify and understand the core principles underlying the extreme heterogeneity of defects of the mitochondrial genome.
In the broader sense, our research helps to rationalise the clinical complexity of rarer mitochondrial diseases, as well as the pathomechanisms of a wide range of common age-related disorders associated with mitochondrial dysfunction (e.g. neurodegeneration, cancer, and ageing itself).
The current position involves studying changes in the mitochondrial genome over age in a range of cell types using techniques we recently developed (Ahier et al Nat Cell Biol 2018). There is also the possibility of studying mutants we have isolated from EMS screens that demonstrate strong resistance to mitochondrial genome defects.
The position is located at the Queensland Brain Institute, a high-level research institute at The University of Queensland, Brisbane, Australia. As well as joining a well-resourced and stimulating research environment, the candidate will have access to many Australian natural wonders, including pristine white sand beaches and ancient subtropical rainforests all within a short distance of Brisbane. Brisbane itself is a cosmopolitan capital with all of the advantages of a big city, but in a relaxed atmosphere.
Previous background in worm genetics will be an advantage.
The initial appointment will be for 1 year and will be renewable for multiple years subject to progress.
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