Functional genomics of C. elegans using NMR-based metabolomics
A postdoctoral position is open at the Centre for Molecular and Cellular Genetics (CGMC), Lyon, France, (Ségalat lab), in the emerging field of NMR metabolomics and metabonomics applied to model organisms.
The overall goal of the project is to demonstrate the power of NMR analysis applied to model organisms. It will be centered on the NMR characterization of C. elegans strains by NMR. The first part of the project aims to solve key physiological questions on the causes of muscle degeneration in C. elegans models of muscle diseases by identifying metabolic variations not detectable by other means. The second part of the project is oriented towards systems biology as it aims at building gene networks based on the NMR signature of mutants, and statistical integration of NMR data with transcriptomic and proteomic data obtained on the same strains.
The project will be carried out in the laboratories of Laurent Ségalat (la Doua campus) and Lyndon Emsley (ENS-Lyon) both located in Lyon. When the Centre for Very High-Field NMR is completed in 2008, both laboratories will be on the la Doua campus.
We are looking for a strongly motivated candidate interested in model organism Genetics and Systems Biology. A background in NMR is desirable but not required. The position is immediately available.
Contact : Laurent Ségalat (segalat AT cgmc.univ-lyon1.fr), tel : 33 4 72 43 29 48
Lyndon Emsley (lyndon.emsley AT ens-lyon.fr), tel : 33 4 72 72 84 86