Reference Genome Annotation Update R64.5
The S. cerevisiae strain S288C reference genome annotation was updated. The new genome annotation is release R64.5.1, dated 2024-05-29. Note that the underlying genome sequence itself was not altered. The chromosome sequences remain stable and unchanged.
R64.5 Annotation Update Summary
This annotation update included (details in table below):
- new ORFs: YDL204W-A, YFR035W-A, YGR016C-A, YMR106W-A, YNL040C-A, YNL155C-A
- new uORFs for existing ORFs: ATG12/YBR217W, ATG19/YOL082W, ATG5/YPL149W, ATG13/YPR185W
- move start downstream: EFM4/YIL064W
- ORF upgraded from Dubious to Verified: YIL059C
R64.5 Annotation Update Details
| Chr | Feature | Description of change | Reference |
|---|---|---|---|
| II | ATG12/YBR217W | New uORF chrII:657824…657835, partially overlaps CDS | Yang Y, et al. (2023) PMID:35363116 |
| IV | YDL204W-A | New ORF chrIV:94133…94285 | Wacholder A, et al. (2023) PMID:37164009 |
| VI | YFR035W-A | New ORF chrVI:226260…226550 | Wacholder A and Carvunis AR (2023) PMID:38048358 |
| VII | YGR016C-A | New ORF chrVII:523353…523246 | Wacholder A, et al. (2023)PMID:37164009, Chang S, et al. (2023)PMID:37927910 |
| IX | EFM4/YIL064W | Move start 84 nucleotides downstream, new coordinates chrIX:242027…242716 | Hamey JJ, et al. (2024)PMID:38199565 |
| IX | YIL059C | Change ORF qualifier from Dubious to Verified because stable translation product detected | Wacholder A and Carvunis AR (2023) PMID:38048358 |
| XIII | YMR106W-A | New ORF chrXIII:480924…481187 | Wacholder A and Carvunis AR (2023) PMID:38048358 |
| XIV | YNL040C-A | New ORF chrXIV:552558…552478 | Wacholder A, et al. (2023) PMID:37164009 |
| XIV | YNL155C-A | New ORF chrXIV:342135…341911 | Wacholder A and Carvunis AR (2023) PMID:38048358 |
| XV | ATG19/YOL082W | New uORF chrXV:168632…168679 | Yang Y, et al. (2023) PMID:35363116 |
| XVI | ATG5/YPL149W | 4 new uORFs: chrXVI:271236…271277, chrXVI:271252…271302, chrXVI:271299…271307, chrXVI:271302…271307 | Yang Y, et al. (2023) PMID:35363116 |
| XVI | ATG13/YPR185W | New uORF chrXVI:907211…907351, partially overlaps CDS | Yang Y, et al. (2023) PMID:35363116 |