Research Positions (Technician to Staff Scientist)

Various research positions (Research Technician to Staff Scientist) are available to employ C. elegans to identify and study the function of genes that cause rare diseases in humans, as a component of the NIH Undiagnosed Diseases Network (UDN). As part of a team effort with other researchers and clinicians, candidate disease gene-variants are identified, knocked into the worm ortholog by Cas9/CRISPR and phenotype assessed. The development of a follow-up independent research program from one or more of the cases is possible. The project is performed under the guidance of professors Tim Schedl & Stephen Pak, co-directors of the Washington University School of Medicine Undiagnosed Diseases Network C. elegans Model Organism Screening Center. For examples of publications from this project see:

  • Huang et al. A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C. Proc Natl Acad Sci. 2022;119(6):e2105228119. PMID: 35121658.

  • Fielder et al. Functional analysis of a novel de novo variant in PPP5C associated with microcephaly, seizures, and developmental delay. Mol Genet Metab. 2022;136(1):65-73. PMID: 35361529.

  • Boulin et al., Functional analysis of a de novo variant in the neurodevelopment and generalized epilepsy disease gene NBEA. Mol Genet Metab. 2021;134(1-2):195-202. PMID: 34412939

Job title and salary are negotiable and based on the applicant’s experience. Experience in C. elegans, genetics, molecular, cellular, developmental or neuro-biology is advantageous, but not required. The desired candidate is a team player with a strong work ethic. International scientists and US citizens are equally eligible for these fully funded positions.

Washington University is a premier medical research institution, highly collaborative with strengths in model organism basic science and clinical research. St Louis is a diverse multi-cultural environment that is friendly, very affordable and has easy access to numerous indoor and outdoor activities.

For more information or to apply, email Stephen Pak ( or Tim Schedl ( To apply, send cover letter, a CV and contact information for three letters of reference.