RS release 3 of the European Variation Archive

We are delighted to announce the third clustered variants release (RS Release 3) from The European Variation Archive (EVA) consisting of 1.2 billion variant loci in 227 species including many supported by the Alliance of Genome resources such as:

  • Mus musculus with 106 million variants
  • Rattus norvegicus with 9.8 million variants
  • Danio rerio with 19 million variants
  • Drosophila melanogaster with 5.6 million variants

This is the first release where the EVA is publishing all existing variants lifted over to current community reference genome versions. The liftover process has remapped and updated 515 million variants.
More information about the new content in the release can be found on the release page of the EVA website [1]

The data from the release is accessible via the following methods:

Bulk download
The variants are available on the EVA FTP site [2] organised by species/assembly listing all the RS IDs in VCF format. The files include current RS accessioned variants, as well as multi-mapped, deprecated and unmapped variants/IDs. More information regarding the format of the general release can be found in the “README_general_info.txt” and known issues in the release are documented in “README_release_known_issues.txt”.

EVA Website
Variants can be searched by RS or SS IDs on the EVA website using the SNP search box [3]

REST Interface
We provide a comprehensive REST API [4] for programmatic access to all of the EVA data by species, study, and RS ID.

We welcome feedback from the community and will aim to incorporate suggestions into future releases. We hope the variants provided are beneficial in future research and the format they are presented in is intuitive. Feedback can be provided using this short survey [5]

For regular updates, please subscribe to our mailing list [6]

The EVA Team

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