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Saccharomyces Genome Database
January 5, 2025
What kind of data does this resource provide ?
The Saccharomyces Genome Database (SGD) is the global knowledgebase for everything related to the budding yeast Saccharomyces cerevisiae. Providing detailed biological information facilitated by advanced search and analysis tools, SGD empowers users to uncover functional links between sequences and gene products across fungi and beyond.
Give me an example of the impact of this resource
The SGD is a comprehensive resource providing the highest quality reference information about the genome and genomic elements of the budding yeast Saccharomyces cerevisiae. S. cerevisiae is a vitally important model organism, which is used extensively in research to provide fundamental insights into eukaryotic genetics, genome maintenance and regulation, and a variety of cellular processes.
The SGD synergises results from a large variety of molecular and biochemical assays reported in the experimental literature, extending this information by assimilating the results of large-scale genomics assays. It provides connections to fungal species and model eukaryotes via orthology, and incorporates formalised and controlled vocabularies to represent biological concepts. SGD also develops tools and integrates third-party software that enhances the work of scientists and educators.
S. cerevisiae is a powerful model system as hundreds of thousands of molecular phenotypes have been reported. This information helps guide research in other model systems, and in human. Many researchers whose work does not focus on budding yeast access the detailed information via the SGD site. However, a much larger number obtain information via one of the downstream resources into which SGD data flows, such as Gene Ontology, UniProtKB and other services provided by NCBI and EMBL-EBI.
Key Facts
- The Saccharomyces Genome Database (SGD) was established in 1993 and is funded by the US National Institutes of Health. It is run by the Department of Genetics at the School of Medicine at Stanford University in the USA.
- The SGD provides the complete genome sequence of Saccharomyces cerevisiae, which consists of approximately 12.1 million base pairs.
- The database includes annotations for over 6,600 protein-coding genes in the Saccharomyces cerevisiae genome.
- SGD features over 50,000 Gene Ontology (GO) annotations, categorising genes by their biological processes, molecular functions, and cellular components.
- SGD is a founding member of both the Gene Ontology Consortium and the Alliance of Genome Resources